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pentobarbital will decrease the extent or impact of larotrectinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will lower the level or result of clozapine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.pentobarbital will lower the level or result of mifepristone by impacting hepatic/intestina